2017 Request for Proposals (Due 3/31/2018)
- Sandi Kwee, MD, PhD, MSc. Analysis of Phospholipids and Other Liver Tissue Metabolites in Chronic Liver Disease. Liver fibrosis is the destructive tissue process underlying all chronic liver diseases. In this project, we will quantify a broad array of metabolites produced in fibrotic liver tissues and determine how their corresponding metabolic pathways are affected. In doing so, we hope to uncover promising diagnostic biomarkers and therapeutic targets for treating liver fibrosis.
- Kazuma Nakagawa, MD. Novel Approach for Early Detection of Life-Threatening Neurological Complications of Preeclampsia with Severe Features. Severe form of preeclampsia can cause life-threatening brain swelling. To date, there is no bedside tool that can be used to screen those who are at risk. This study will explore the potential use of pupillometer to detect individuals who are at risk for potentially life-threatening brain swelling after preeclampsia.
2016 Request for Proposals (due 1/20/2017)
- Michael Hayashi M.D. Fall From Standing as a Marker of Frailty; Are Outcomes Better for Elderly Patients After
High Energy Falls? Hawaii’s large active elderly population results in frequent emergency room admissions
injuries such as falls.
This study will see if individuals sustaining ground level falls may experience worse short and long-term results
compared to elderly people that fall from a height due to differences in baseline health.
- Darcy Day, RN and Kara Terada, RN.
Correlation of Nasal Cannula End-Tidal Carbon Dioxide Concentration with Need for Critical Resources
for Blunt Trauma Patients During the First Two Days of Hospital Presentation.
End-tidal carbon dioxide monitoring via nasal cannula is a non-invasive common device that can assist
in the monitoring of a patient’s perfusion status. Early identification and treatment of trauma patients that may
require critical resources is crucial to obtaining the needed resources to optimize trauma patient care.
2015 Request for Proposals (due 1/8/2016)
- Sayuri Suzuki, PhD. High-throughput screening against TRPM7 to identify anti-proliferative cancer drugs. Cancer is among
the leading causes of death worldwide. We have found that cancer cells need a particular ion channel protein called TRPM7 in order
to grow and stop growing when that protein is blocked. Our goal is to discover novel TRPM7 blockers with properties that enable them
to be used as anti-breast cancer drugs. We propose to screen chemical compound collections for TRPM7 blockers, test the found
inhibitors for potency and selectivity against the TRPM7 target, and measure the growth inhibition and anti-breast-cancer efficacy
on cancer cells.
- Clay Wakano, PhD. High-throughput drug screening against TRPM2, a novel protein involved in neurodegeneration and cancer cell
proliferation. The development of new medicines is at the frontline of translating basic research into patient care. The goal of
this project is to validate the effectiveness of drug candidates against the Transient Receptor Potential Melastatin, subfamily 2,
ion channel involved in human neurodegenerative and oncologic diseases.
2014 Request for Proposals (due 1/9/2015)
- Aaron Cullen, Ph.D. Bithionol Derivatives as Anti-Cancer Therapeutics.
Cancer is one of the leading causes of death worldwide. The following proposal outlines a plan for developing new anti-cancer agents.
Out goal is to create a novel set of compounds, test these candidates for anti-cancer ability, and ultimately advance these candidates
into human clinical trials.
- Scott Kuwada, M.D. A novel serum-based detection of gastrointestinal malignancies.
Colorectal cancer is the second leading cause of cancer deaths in the U.S. Just over half of all eligible person in the U.S. undergo
colorectal cancer screening. The options for screening (stool studies, colonoscopy, barium enema) are not tolerable, invasive and
expensive. We propose to develop a blood-base colorectal cancer screening test that would be easy to perform, effective and relatively
2013 Request for Proposals (due 1/27/2014)
- Malika Faouzi, Ph.D. STIM/Orai channels as new therapeutic targets in pancreatic cancer.
Pancreatic cancer is the fourth most deadly cancer in the United States. Calcium, regulated by specific proteins, is a critical
nutrient for tumor growth. The present proposal will test the efficacy of an FDA-approved drug in blocking these proteins and
may lead to a novel therapeutic approach for pancreatic cancer.
2013 Requests for Proposals (due by 4/16/2013)
- May Rose Dela Cruz, M.PH. Increasing HPV Screening through Targeted Education in Hawai'i.
'Imi Hale Native Hawaiian Cancer Network seeks to advance cancer research by developing and testing targeted educational materials for
children 11-18 years old who are not vaccinated with the HPV vaccine. Almost all cervical cancer can be prevented through widspread
uptake of the HPV vaccine.
- Scott Kuwada, M.D. Gastrointestinal Stromal Tumor (GIST) Epidemiology and Genotypes in Hawaii.
Gastrointestinal stromal tumors (GIST) are the most common type of tumors arising from walls of the digestive tract. Hawaii has the
highest number of cases of GIST per every 100,000 people in Hawaii compared with all other regions of the United States. We have
found that GIST is much more common in Asian and Pacific Islanders than Caucasians. We would like to determine if a common stomach
infection increases the risk for developing GIST. Treatment of GIST that has spread to multiple sites in the body requires
treatment with the drug imatinib. Certain mutations in the tumors cause resistance to imatinib but detection of these mutations in
GIST is not routinely done in Hawaii. We wish to determine if looking at these mutations would predict which patients fail to
response to imatinib.
- Reinhold Penner, Ph.D. Pre-Clinical and Clinical Efficacy of Antibiotic AB1 in Ovarian and Pancreatic Cancer.
Calcium is a critical nutrient needed for cancer cell division and tumor growth. It is regulated by specific proteins in cells.
One of these mechanisms is tightly linked to the calcium storage compartments of cells. Certain antibiotics interfere with this
mechanism, thereby causing ovarian and pancreatic cancer cells to stop growing. The present proposal will test an FDA-approved
antibiotic in a pancreatic mouse model and in a pilot ovarian cancer clinical trial in humans for its effectiveness to stop tumor
growth. This may directly lead to a novel adjuvant therapy for ovarian and pancreatic cancer patients.
2012 Requests for Proposals (due by 1/15/2013)
- Kevin Christensen, M.D. Bisphosphonate-associated atypical femur fractures versus osteoporotic femur fractures: a histologic
- Susan Steinemann, M.D., FACS Optimizing Trauma Team Performance through Education, Pre-briefing and Debriefing.
Early care of the injured ("trauma") patient requires fast and efficient teamwork between many healthcare providers (the "trauma team).
Failures in teamwork and team communication can harm the patient. This project investigates differences in knowledge, perception and
teamwork among trauma team members, and how structured education might improve teamwork.